MIMEDX – AXIOFILL

AXIOFILL® is a biocompatible acellular human placental extracellular matrix (ECM) derived from the placental disc. It is intended for use in the replacement or supplementation of damaged or inadequate integumental tissue. Clinical use examples include deep, tunneling, or irregular soft tissue deficits and incision management in surgical applications.

As a particulate, AXIOFILL presents a versatile option for various clinical applications and is easy to apply dry or hydrated to use in paste form.

A Replacement/Supplement of Damaged/Inadequate Integumental Tissue



AMNIOEFFECT provides a protective barrier that supports the healing cascade and protects the wound bed to aid in the development of granulation tissue in acute and chronic closures.

Provides a Biocompatible Extracellular Matrix



Gentle processing preserves the ECM components. Early scientific data in a nude mouse model shows AXIOFILL supports site appropriate function in tissue by allowing cell attachment, new collagen formation on the matrix, and new blood vessel formation.1

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Product Advantages

  • A lyophilized, biocompatible, and human extracellular matrix derived from the placental disc

  • For use in the replacement or supplementation of damaged or inadequate integumental tissue

  • Versatile and easy to use: apply dry or hydrated as a paste

  • Economic alternative for larger soft tissue deficits

  • Compatible with negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBOT)

  • Early scientific data in a nude mouse model shows AXIOFILL supports site appropriate function in tissue by allowing cell attachment, new collagen formation on the matrix, and new blood vessel formation1

     

Clinical Use Examples

AXIOFILL’s handling properties make it versatile for applying to complex, soft tissue deficits in its dry form, or as a paste. Clinical use examples may include:

Dry Applications

  • Partial and full thickness wounds

  • Diabetic Foot Ulcers (DFUs)

  • Venous Leg Ulcers (VLUs)

  • Pressure Ulcers (PUs)

  • Chronic vascular ulcers

  • Trauma wounds (abrasions, lacerations, burns, and skin tears)

  • Draining wounds

Hydrated/ Paste Applications

  • Tunnel/undermined wounds

  • Fistulae

  • Deep, irregular wounds

  • Incisions

  • Surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence)

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AMNIOFILL Processing & Details

AXIOFILL is processed using PURION, a unique patented method for placental-based allografts that is in accordance with the American Association of Tissue Banks (AATB) standards. The product is derived from placental tissue donated by healthy, consenting mothers who have given live Caesarean section birth in the US.

MIMEDX’s patented PURION process preserves extracellular matrix components and other matrix-bound proteins. For an additional level of safety, the product is terminally sterilized.
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